Recent research has turned human breast cancer cells into fat cells and this a promising step in the right direction of the fight against cancer.
Researchers used a pathway that the cancer cells like to take and managed to manuver with it.
Stem cells turn into more differentited cells which then are able to differentiate into whatever the body needs, this pathway is called Epithelial-mesenchymal transition EMT.
Cancer tends to take this pathway and go from from epithelial to mesenchymal and it also takes the reverse pathway mesenchymal to epethylial.
Researchers took mice with and induced it with human breast cancer. They treated the mice with diabetic drug and with cancer treatment in order to see what will happen to this EMT pathway.
Due to this drugs when the cancer cells started using the EMT pathway intead of spreading they turned into fat cells (adipogenesis).
The study shows results where cells that use the EMT pathway more frequently tend to become fat cells.
Not every cell changed but the ones that did, they didn’t change back, and also stopped multyplying.
How does it work
The cancer treatment drug increases the change of cancer cells into stem cells, then increases the conversion of those stem cells into fat cells.
The diabetic drug was less important but it also helped to turn the stem cells into fat cells.
With the combination of the two drugs the change from cancer cell to fat cell was more efficient.
This two drugs are FDA approved which makes it easier to get this type of treatment into clinical trials.